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The very first asymmetric total synthesis of conolidine was created by Micalizio and coworkers in 2011.[2] This synthetic route allows use of both enantiomer (mirror graphic) of conolidine through an early enzymatic resolution."We verified that conolidine binds to the freshly determined opioid receptor ACKR3, although exhibiting no affinity for the

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We use cookies to improve your practical experience with us. To find out more - remember to confer with our privacy policy."We verified that conolidine binds into the newly discovered opioid receptor ACKR3, while demonstrating no affinity for the opposite 4 classical opioid receptors. By doing so, conolidine blocks ACKR3 and helps prevent it from t